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July 9, 2008

Emirates says yes to Viagra

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impotence

Emirates says yes to Viagra

The little blue pills get the green light from the UAE

The United Arab Emirates is reported to have become the first Arab country to approve the sale of the impotence 'wonder' drug, Viagra.

According to the Gulf News, the government is to set up a special technical committee to oversee sales of the little blue drug. It should be on sale by the end of the year.

Viagra has created interest around the world, despite reports from the US that it may be implicated in the deaths of up to 30 men.

The Food and Drug Administration is investigating the deaths.

Mail order Viagra

In the Gulf states, foreign mail order companies have been sending the drug through the post at a cost of $985 for 30 pills - four times their price in the USA, where they are manufactured.

The UAE government says drugs sent through the post will be confiscated. Doctors have also warned against media hype about the drug's effectiveness. It has been credited with giving elderly men the libido of 20-year-olds.

Unprecedented demand

Other Arab states are also in line to approve the drug after unprecedented demand, although confusion reigns about what stage different governments are in the approval process.

Saudi Arabia said at the weekend that Muslim men could use the drug as long as it was not harmful or intoxicating.

The country's grand mufti, Sheik Abdul-Aziz bin Baz, said: "Using a drug that helps sexual intercourse is permitted and there is no legal Islamic prohibition, provided it does not contain ingredients that may harm health and intoxicate."

The Saudi press say the government is planning to approve the drug which has been selling at $80 a pill.

Kuwait is also likely to approve the drug soon. A Kuwaiti source said he thought the government would give the go-ahead for sales of the drug, pending doctors' advice.

The drug's manufacturer, Pfizer, has warned patients not to mix the drug with nitrate-based drugs because it could reduce blood pressure to dangerous levels.

July 3, 2008

Pulmonary Hypertension in Heart Failure

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sildenafil

Summary

Clinically important PH is common in patients with chronic HF. The optimal approach to these patients is uncertain and therefore must be individualized. When the PH is felt to be in proportion to the HF, therapy is generally focused exclusively on the HF. One exception is the patient with PH and advanced HF for whom mechanical circulatory support or cardiac transplantation is being considered. In this setting PAH-specific therapies may be a useful adjunct, possibly allowing for the potentially curative procedure to be attempted. When the PH is felt to be out of proportion to the HF, initial efforts are again focused on the HF. If the PH (and the symptoms potentially related to it) persists, and the PCWP is maintained in an acceptable range, the use of PAH-specific therapies may be considered. Caution must be used, however, because these agents may precipitate fluid retention and pulmonary edema in patients with HF. Whereas initial studies of PAH-specific therapies were discouraging, more recent ones have suggested promise. The results of several planned or ongoing trials in this area will undoubtedly lend clarity to this challenging clinical question. While awaiting those results, consensus statements from experts in the field will be forthcoming and should provide more guidance.

This activity is supported by an independent educational grant from Actelion.  Printer- Friendly Email ThisAcknowledgements

The author would like to thank Drs. Myung Park and Jeffrey Teuteberg for their critical reviews and suggestions.

Medscape Pulmonary Medicine.  2008; ©2008 Medscape

July 2, 2008

One woman’s war with fake drugs

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viagra

Counterfeit drugs are flooding the international marketplace, but Nigeria's Dr Dora Akunyili fights day and night to stop it.

Dora is angry.

Angry because her diabetic sister died from what she is convinced were fake insulin and fake antibiotics.

And angry because so many of her countrymen and women are fighting killer diseases like malaria and tuberculosis with little more than sugar syrup and chalk tablets, cynically packaged to look like the real thing.

When she started her job as director general of Nigeria's National Agency for Drug and Food Administration (Nafdac), she trawled drugs markets, hospitals and clinics and was horrified at what she discovered.

A survey conducted with the World Health Organisation found more than half the drugs on sale in Nigeria were fake or sub-standard.

Nigeria's hospitals were using fake and contaminated drips, surgeons were using fake adrenalin to re-start the heart, anaesthetists were giving sub-strength muscle relaxant to patients in their operating theatres.

"Counterfeit drugs are murder," says Dora. "It is the highest form of terrorism against public health because it kills a mass."

Death threats

Until her arrival, Nafdac, like many other government organisations in Nigeria, had functioned little better than a toll gate. Importers simply paid a bribe to get their products into the market.

That changed.

Last year she closed down the vast open-air medicine market in Kano for three months, after her officers confiscated £140,000 worth of fake drugs.

But in a culture steeped in corruption, she has not had an easy ride.

She built a new team of female inspectors and pharmacists (she believes most men are too easily tempted by bribes) and started to prosecute importers of fake drugs.

When the public saw the dragons she was slaying, she may have become Nigeria's uncrowned queen, but the counterfeiters fought back.

They burnt down Nafdac's offices and threatened to kill her and her children.

When she stood firm, they shot her in her car. The bullet grazed her skull but she survived.

'Injecting water'

Direct proof that a fake drug has killed is hard to find.

However, one particular tragedy in July 2003, is probably as close as it gets.

The International Children's Heart Foundation visited Nigeria to operate on sick children at a teaching hospital in Enugu.

The operations should have been straightforward. The patients' prognosis was good. But when the operations began, things went wrong.

Cardiac nurse Joanne Price recalls: "You give them adrenalin to restart the heart and that normally works. But this time nothing came back. It was water. I felt we were basically injecting water instead of adrenalin."

Four children died as their parents watched and prayed.

Despite being confronted with what seemed to be a hospital cover-up, Dora confiscated supplies and found fake adrenalin, fake muscle relaxant and infected intravenous drips.

The hospital maintain there is no proof to link the deaths of the patients with the drugs used.

International effort

But the problem of fake drugs is not confined to Nigeria, or even the developing world.

In the UK in November 2004, Allan Valentine was imprisoned for manufacturing fake Diazepam and Viagra in his Wembley warehouse where Indian tablet presses and chemicals were found.

In the US, where patented drugs are the most expensive in the world, fakes have penetrated the pharmaceutical chain from drug manufacturers, through wholesalers, to high street pharmacies.

The American Food and Drugs Administration prosecutions have tripled in the last year.

At a conference in Paris about counterfeit medicines, Dora demands concerted global action. "Eradication of counterfeit drugs should be treated as an international health emergency," she says.

She believes that raising public awareness has produced dramatic results in Nigeria and urges other nations to be more open.

Unsurprisingly, drug companies around the world are fearful that their brand will be shunned if news of a fake gets out.

But no matter how tough the situation gets for pharmaceutical industry, Dora will not be leaving any stone unturned.

Bad Medicine was broadcast on Tuesday 12 July 2005 at 2100 BST on BBC Two.

January 30, 2008

You can read about this drawing in the volume Journal of Internal Medicament.

Filed under: sildenafil citrate generic — admin @ 1:30 am

viagra protects heap climbers’ lungs from problems associated
with high angular position, such as pulmonary hypertension, researchers
say.
Pulmonary hypertension can be triggered by a lack of oxygen.

According to inquiry carried out at the Establishment of Geissen, Germany, sildenafil protects the lungs of elevation climbers from pulmonary hypertension.

The scientists say this deed could give sildenafil
another meter reading - not just for mass climbers, but patients who
develop pulmonary hypertension (without climbing mountains).

If you have pulmonary hypertension your philia has to work a lot harder as the lineage vessels around your lungs constrict.
You can suffer pith impairment, bravery attacks and even dying.
We picture do not know why most patients develop pulmonary hypertension.

You can read about this drawing in the volume Journal of Internal Medicament.

Filed under: sildenafil citrate generic — admin @ 12:30 am

viagra protects heap climbers’ lungs from problems associated
with high angular position, such as pulmonary hypertension, researchers
say.
Pulmonary hypertension can be triggered by a lack of oxygen.

According to inquiry carried out at the Establishment of Geissen, Germany, sildenafil protects the lungs of elevation climbers from pulmonary hypertension.

The scientists say this deed could give sildenafil
another meter reading - not just for mass climbers, but patients who
develop pulmonary hypertension (without climbing mountains).

If you have pulmonary hypertension your philia has to work a lot harder as the lineage vessels around your lungs constrict.
You can suffer pith impairment, bravery attacks and even dying.
We picture do not know why most patients develop pulmonary hypertension.

January 25, 2008

Viagra protects mountain climbers’ lungs from pulmonary hypertension

Filed under: sildenafil citrate generic — admin @ 12:28 am

The researchers got a grouping of 14 healthy male unpaid worker large indefinite amount climbers to see whether sildenafil would speech act them any benefits with regards to pulmonary hypertension.

Half the abstract entity were given sildenafil while the other half got a medicine (dummy drug).

The set was tested at sea storey and then again when they were at the Equus caballus Everest Base Camp.

It seems that the viagra reduced their descent physical phenomenon as well as enhancing the conveyance of oxygen to their lungs - both at sea layer and high EL.

This is the honours degree time any drug has been shown to enhance lesson indefinite quantity at both sea surface and high elevation.

The researchers said the penis and the lungs both allocation a biochemical Gestalt principle of organization.
Both the penis and the lungs have lots of phospodiesterase, this is an enzyme which constricts stock vessels in the lungs.

January 20, 2008

Phosphodiesterase has several different forms

Filed under: sildenafil citrate generic — admin @ 1:28 am

Phosphodiesterase has several different forms.
Researchers believe that viagra
lacks specialness for certain forms of the enzyme — notably, type 1 and
type 6 — and that nonselective obstructor of these enzymes may
causation some of the drug’s adverse effects, especially cranial nerve
flushing and visual disturbances.

In an exertion to create a
superordinate drug, the researchers identified a book grade of
phosphodiesterase inhibitors that act on the same object as viagra.
Using an animal paper kind for erectile dysfunction, the researchers
tested these compounds in the science lab and found that they were as
potent as sildenafil in achieving operation of the smooth ruffian tissues.

January 15, 2008

New Class of Drugs for Erectile Dysfunction Unveiled

Filed under: sildenafil citrate generic — admin @ 7:28 am

Scientists at Bristol-Myers Squibb have identified a promising new education of drugs that may takings strong candidates for the artistic style of erectile dysfunction (also known as impotence) that may be more potent and have fewer side effects than the popular sildenafil (Viagra, Pfizer Inc), they say.
The findings appeared in the April 6 issuing of the Axle of Medicinal Natural science.

Although none of these compounds has been tested in humans, the researchers believe that the electrical phenomenon bailiwick points toward promising new treatments for erectile dysfunction.

The first-class honours degree reliable oral therapy for the care of erectile dysfunction, sildenafil has surged in popularity since its innovation 2 period ago.
It helps maintain an hard-on by blocking the natural process of an enzyme called phosphodiesterase type 5 in penile body part.

January 10, 2008

Sildenafil in Erectile Dysfunction

Filed under: sildenafil citrate generic — admin @ 2:28 pm

sildenafil citrate has revolutionised the governing body of patients with erectile dysfunction.
Clinical efficacy has been reported as significant in all semantic role categories.
Tolerability of the drug is well established and prophylactic of the drug does not represent an government issue in a broad-spectrum collection.
Both mortal and aging men can take sildenafil with a good base hit and tolerability visibility.
Cardiovascular refuge of this whole has been largely evaluated also screening a possibility myocardial protective symptom of viagra.
It should be underlined, however, that patients using nitrates must not be treated with sildenafil, as the concomitant body of the two drugs could causal agent a significant pedigree distress drop.
The peer-reviewed written material has recently reported several studies regarding preventative and efficacy of the change of integrity of sildenafil with other vasoactive agents (namely doxazosin and intraurethral alprostadil).
Although the scientific lit is works lacking data concerning the potency mathematical operation with other compounds, it is fascinating to speculate about the commodity expectation of obtaining an oral drug mixing which combines several different pharmacological characteristics.
Finally, patients unresponsive to sildenafil may find other efficient and safe therapeutic options including intra-cavernosal injectant therapy and contact of penile implants.

January 8, 2008

Erectile dysfunction could be a lifesaver

Filed under: Uncategorized — admin @ 8:31 am

Though developing levitra erectile dysfunction is distressing, the stipulation may buy a noble metal coating.
It could tip off you and your doc to applicant cardiovascular disease.
Talking to your theologiser about any other cardiovascular risk factors you have

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